Platelet-Rich Plasma Treatment for Peripheral Neuropathy

Peripheral neuropathy is a painful condition where the nerves furthest away from your spine become damaged or diseased. The most common location for peripheral neuropathy to begin is in the feet. It can start off as a tingling sensation and, over time, increases to a burning pain as damage to the nerve increases. Eventually, it can lead to a numb sensation in the toes, ball of the foot and then the whole foot. If this occurs, it can cause balance issues, foot ulcers, and damage to the skin between the toes as you can no longer feel pain or sensation in the foot.

Peripheral neuropathy can be caused by several conditions, such as diabetes or carpel tunnel syndrome. To begin with, it is important to address the root cause of the neuropathy; if at all possible. This is done ideally before addressing the nerve damage directly. This means, for example, we address (and ideally eliminate) carpel tunnel syndrome first, before treating the nerves in the wrist and the hands first.

About the Treatment

Platelet-rich plasma is a safe and effective treatment for peripheral neuropathy. Platelet-rich plasma involves drawing an amount of blood from the patient, spinning it in a special centrifuge (we use Arthex Angel System) which extracts the platelet-rich plasma (PRP). This PRP is then injected to the affected nerves in the foot or wrist. The procedure is conducted in the office and should be repeated up to three times. Research shows a decrease in pain and increase in sensation within three months. However, with my patients, I have seen improvements in 4 weeks with an increase in sensation and decrease in pain.

For more information on how PRP works click here

Research

A 2019 study was conducted on 60 individuals with type II diabetes with concurrent diabetic neuropathy. Half the group received PRP treatment while the other half did not. The group receiving PRP showed significant improvement in pain and numbness at 1 month, 3 months, and 6 months follow up visits.

Another study specifically focused on carpal tunnel syndrome found that 1 injection of PRP to the wrist significantly decreased pain and numbness at 1, 3 and 6 months.

Here are the most recent studies researching PRP treatments for peripheral neuropathy, the year they were released and the outcome. Click the link for further information

Study Year Outcome (Positive or Negative) Link
Perineural Platelet-Rich Plasma for Diabetic Neuropathic Pain, Could It Make a Difference?

 

2019 Positive https://www.ncbi.nlm.nih.gov/pubmed/31298289
Six-month efficacy of platelet-rich plasma for carpal tunnel syndrome: A prospective randomized, single-blind controlled trial.

 

2017 Positive https://www.ncbi.nlm.nih.gov/pubmed/28273894
Sensory improvement of leprosy peripheral neuropathy in patients treated with perineural injection of platelet-rich plasma. 2014 positive https://www.ncbi.nlm.nih.gov/pubmed/24168291

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